OcaB Is Required for Normal Transcription and V(D)J Recombination of a Subset of Immunoglobulin κ Genes
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منابع مشابه
OcaB Is Required for Normal Transcription and V(D)J Recombination of a Subset of Immunoglobulin κ Genes
OcaB, a transcriptional coactivator also known as Bob-1 or OBF-1, was isolated on the basis of its ability to enhance transcription of immunoglobulin (Ig) genes in vitro. Paradoxically, OcaB(-/-) mice showed no apparent deficiency in Ig gene transcription, only cellular immune defects including absence of germinal centers (GC) and decreased numbers of immature B cells; the genes targeted by Oca...
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ژورنال
عنوان ژورنال: Cell
سال: 2002
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(02)00911-x